Large-scale linkage analysis of 1302 affected relative pairs with rheumatoid arthritis
نویسندگان
چکیده
منابع مشابه
Large-scale linkage analysis of 1302 affected relative pairs with rheumatoid arthritis
Rheumatoid arthritis is the most common systematic autoimmune disease and its etiology is believed to have both strong genetic and environmental components. We demonstrate the utility of including genetic and clinical phenotypes as covariates within a linkage analysis framework to search for rheumatoid arthritis susceptibility loci. The raw genotypes of 1302 affected relative pairs were combine...
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OBJECTIVE The conventional affected sib pair methods evaluate the linkage information at a locus by considering only marginal information. We describe a multilocus linkage method that uses both the marginal information and information derived from the possible interactions among several disease loci, thereby increasing the significance of loci with modest effects. METHODS Our method is based ...
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ژورنال
عنوان ژورنال: BMC Proceedings
سال: 2007
ISSN: 1753-6561
DOI: 10.1186/1753-6561-1-s1-s100